4-{[(tert-butoxycarbonyl)amino]methyl}piperidinium

4-{[(tert-butoxycarbonyl)amino]methyl}piperidinium - Names and Identifiers

Name	4-(Boc-Aminomethyl)piperidine
Synonyms	BUTTPARK 4357-92 4-Boc-aminomethyl-piperidine 4-(Boc-Aminomethyl)piperidine 4-(BOC-AMINOMETHYL)PIPERIDINE 4-N-Boc-Aminomethyl piperidine 4-N-BOC-AMINOMETHYL PIPERIDINE 4-(Boc-aminomethyl) piperidine 4-(2-Boc-Aminomethyl) piperidine 4-(2-BOC-AMINOMETHYL) PIPERIDINE 4-AMINOMETHYLPIPERIDINE, BOC PROTECTED 4-Aminomethylpiperidine, BOC PROTECTED tert-butyl (piperidin-4-ylmethyl)carbamate 4-(TERT-BUTOXYCARBONYLAMINOMETHYL)PIPERIDINE 4-(TERT-Butoxycarbonylaminomethyl)piperidine 4-(T-Butyloxycarbonyl-Aminomethyl)-piperidine 4-(T-BUTYLOXYCARBONYL-AMINOMETHYL)-PIPERIDINE 4-(TERT-Butyloxycarbonyl-Aminomethyl)-piperidine 4-(TERT-BUTYLOXYCARBONYL-AMINOMETHYL)-PIPERIDINE 4-{[(tert-butoxycarbonyl)amino]methyl}piperidinium tert-butyl (piperidin-4-ylmethyl)carbamate hydrochloride
CAS	135632-53-0
InChI	InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-8-9-4-6-12-7-5-9/h9,12H,4-8H2,1-3H3,(H,13,14)/p+1

4-{[(tert-butoxycarbonyl)amino]methyl}piperidinium - Physico-chemical Properties

Molecular Formula	C11H22N2O2
Molar Mass	214.3
Density	0.981±0.06 g/cm3(Predicted)
Melting Point	106 °C
Boling Point	321.8±15.0 °C(Predicted)
Flash Point	148.4°C
Solubility	Soluble in DMSO.
Vapor Presure	0.00029mmHg at 25°C
Appearance	White solid
pKa	12.72±0.46(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
MDL	MFCD01631214

4-{[(tert-butoxycarbonyl)amino]methyl}piperidinium - Risk and Safety

Risk Codes	R34 - Causes burns R36/38 - Irritating to eyes and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
UN IDs	3259
HS Code	29333990
Hazard Note	Corrosive
Hazard Class	IRRITANT
Packing Group	Ⅲ

4-{[(tert-butoxycarbonyl)amino]methyl}piperidinium - Introduction

4-Boc-aminomethylpiperidine (-) is an organic compound. Its properties are as follows:

1. Appearance: 4-Boc-aminomethylpiperidine is a white crystalline solid.
2. Chemical structure: Its chemical structure contains an N-methyl piperidine ring and a Boc(tert-butoxycarbonyl) protecting group.
3. Solubility: 4-Boc-aminomethylpiperidine has good solubility in common organic solvents.

4-Boc-aminomethylpiperidine has a wide range of uses in organic synthesis, commonly used in the following aspects:

1. As an intermediate: It can be used as an intermediate for the synthesis of drugs, dyes and other organic compounds. For example, it is possible to introduce an amino function by removing the Boc protecting group.
2. Acylation reaction: 4-Boc-aminomethylpiperidine can be used for acylation reaction, and the anhydride reacts with it to generate acylated product.

A common method for preparing 4-Boc-aminomethylpiperidine is by N-methylation of piperidine and using Boc acid to protect the hydroxyl group. Specific steps are as follows:

1. Reaction: The piperidine is reacted with a methylating agent (such as methyl sodium iodide) to obtain N-methyl piperidine.
2. Protection: 4-Boc-aminomethylpiperidine is obtained by reacting N-methylpiperidine with Boc acid.

The following safety information should be noted when handling 4-Boc-aminomethylpiperidine:

1. toxicity: 4-Boc-aminomethylpiperidine may produce certain toxicity to the human body, so protective gloves and respirators should be worn during operation.
2. Avoiding light preservation: 4-Boc-aminomethylpiperidine should be sealed and stored in a cool, dark place to prevent its degradation by light.
3. fire: it is a flammable substance, should avoid contact with the fire source.
4. Waste disposal: Waste should be disposed according to local regulations and should not be dumped at will.

Last Update：2024-04-09 20:49:11